Main text Please take note of the following when preparing your manuscript for PNAS: Do not include statements of novelty or priority. Avoid laboratory jargon. Use correct chemical names. Specify ...

NIR-II/SWIR (1,000 to 3,000 nm) fluorescence imaging-guided surgical navigations in pre-clinical murine cancers have largely improved the tumor margin delineation and resection precision. Herein, we ...

The Earth’s rotation has been decelerating throughout its history due to tidal dissipation, but the variation of the rate of this deceleration through time has not been established. We present a ...

The discovery of Lophiostroma leizunia Jeon sp. nov., a 480-My-old phosphatic stromatoporoid sponge from South China, revolutionizes our understanding of early reef ecosystems and biomineralization.

A cure for chronic hepatitis B requires eliminating or permanently silencing covalently closed circular DNA (cccDNA). A pivotal target of this approach is the hepatitis B virus (HBV) X protein (HBx), ...

Many cities seek to alleviate extreme heat via planting trees. However, the cooling achieved by such programs is debated because previous analyses address scales much smaller than the whole-city scale ...

The expansion of marine protected areas (MPAs) is a crucial part of global conservation efforts (1). The “30x30” initiative, for example, aims to protect at least 30% of the world’s oceans by 2030 ...

We thank Jun Chen for providing wdr5 mutant, Anming Meng for providing rnaseh1 MO, Dengli Hong for providing 2×HBD, and Yu Sun for assistance during the experimental process. This work was supported ...

Chronic inflammatory skin disorders affect millions worldwide. Our study reveals a role for acetylcholine (ACh), a molecule typically associated with neuronal signaling, in regulating skin health. We ...

The kinetics and pathway of most catalyzed reactions depend on the existence of interface, which makes the precise construction of highly active single-atom sites at the reaction interface a desirable ...

Lockdowns were implemented to reduce the transmission of the COVID-19 virus. However, it is unclear how severely curtailed physical interaction shapes individual behaviors that are considered vital ...

Large-scale cooperation is central to the success of the human species (1). Yet its origins remain poorly understood. Canonical explanations, such as kin altruism (2, 3), reciprocity (4 – 6), and ...