SMA is a motor neuron disease characterised by generalised muscle atrophy and weakness. It is caused by the dysfunction and eventual death of motor neurons, due to deletions of SMN1 in 95% of patients ...

Aim ‘Did not attends’ (DNAs) are a frequent occurrence at outpatient clinics. These affect waiting list times, cost the hospital money, and may mean children are not receiving the medical care that ...

Aims Continuous subcutaneous infusion of insulin (CSII) via an insulin pump is believed to provide more physiological and flexible control of type 1 diabetes compared with injection regimens such as ...

Objective To investigate a possible association between fever admissions and 4 component Meningococcal B (4CMenB). Design 4CMenB is given at 8 and 16 weeks in the first year of life. Self-controlled ...

Purpose Children with Trisomy 21 are at increased risk of death compared to age-matched controls. We recently undertook a retrospective review of mortality in Trisomy 21 in our tertiary non-cardiac ...

Background Mental health problems are prevalent in children and young people (CYP). Children with neurodevelopmental disorders such as ASD have co-morbid mental health difficulties which add to the ...

Aims To explore the experiences and perceptions of senior medical and nursing staff regarding the advance care plan (ACP) in children and young persons (CYP) with life-limiting conditions and ...

Aims Maternal breastmilk (MBM) is the one of the most important interventions a preterm infant can receive. It reduces morbidity, improves neurodevelopmental outcome and reduces the incidence of ...

Methods We used novel linkage between health and education records from the Education and Child Health Insights from Linked Data (ECHILD) database to develop a whole-country cohort of children ...

Objectives Asthma is the most common chronic condition in children, affecting 2–3 in every primary school class.1 Asthma disproportionately affects children living in poverty due to air pollution, ...

BACKGROUND In recent years photopheresis, an extracorporeal form of photochemotherapy using psoralen and ultraviolet A irradiation of leucocytes, has been claimed to be an effective form of ...

Background Cystic fibrosis (CF) affects over 8000 people in the UK and an estimated 100 000 globally. Prognosis has improved greatly over the last few decades, but patients still have a reduced life ...