A cure for chronic hepatitis B requires eliminating or permanently silencing covalently closed circular DNA (cccDNA). A pivotal target of this approach is the hepatitis B virus (HBV) X protein (HBx), ...

Long-term light at night (LAN) exposure poses a health threat to nocturnal lab animals. Whether diurnal animals suffer the same deleterious effect imposed by LAN and how it works are still open ...

The carbon isotopic composition of atmospheric CH 4 (δ13 C CH4) is a powerful tool for tracking the sources and sinks of atmospheric CH 4. Different CH 4 sources have distinctive δ 13 C CH4 values: ...

Recent reports suggest that the US administration plans to eliminate the Environmental Protection Agency’s (EPA’s) Office of Research and Development (ORD) (1, 2). Most staff would be cut, with ...

Circulating monocytes are recruited to the tumor microenvironment, where they can differentiate into macrophages that mediate tumor progression. To reach the tumor microenvironment, monocytes must ...

Crystallization of the lunar magma ocean yielded a chemically unique liquid residuum named KREEP. This component is expressed as a large patch on the near side of the Moon and a possible smaller patch ...

Sporting events can bring people together and forge strong loyalties, but the mechanisms behind their social impact remain unclear. Our study reveals that events peripheral to the game, such as the ...

Rapid pathogen detection is crucial for effective disease management, particularly in bloodstream infections. Current molecular diagnostics often require nucleic acid preamplification, adding time and ...

The identification of SLC35F2 as the eukaryotic transporter of queuine and queuosine is key to understanding how these micronutrients are salvaged from the human gut and distributed to different body ...

We demonstrate that substitutionally inert octahedral metal complexes, such as the iridium (III) carbene complex (1a), provide a useful source of potent inhibitors for unexplored oncogenic protein ...

The choice between different approaches to decision-making is no mere technical issue; if different approaches yield different results, then how we make decisions changes the decisions we make. While ...

Cell-based therapy using satellite stem cells (SSCs) holds tremendous potential for enhancing muscle regeneration. However, conventional isolation methods often yield heterogeneous cell populations ...