Background The gold standard for diagnosis of meningitis is the isolation of a pathogen from cerebrospinal fluid (CSF) by culture or PCR. However, treatment is routinely commenced based on CSF ...

Objective Screening for critical congenital heart disease (CHD) with prenatal ultrasound or postnatal pulse oximetry has the potential to improve outcome. To guide screening recommendations, this ...

Most children in hospital who are clinically deteriorating are monitored regularly, and their treatment is escalated effectively. However a small, but significant, number of deteriorating children ...

Tell me how you measure me, and I will tell you how I will behave.Eliyahu Moshe Goldratt1 The pursuit of patient safety is a key component of the wider endeavour to improve quality of healthcare ...

There is increasing evidence that health and development in adult life is influenced or “programmed” by factors, including nutrition, operating during foetal life and infancy. Early nutrition in a ...

Results At initial evaluation, 3 of the 150 children included were diagnosed with TB disease (2.0%). The prevalence of LTBI was 58.7%. The incidence of LTBI was 19.9 per 100 children per year, and was ...

Background Gender identity services for children and young people are currently being reorganised in England and Wales. Provision is required to negotiate clinical uncertainty and a public debate that ...

One million patients with head injuries attend emergency departments each year in the UK, of whom as many as 50% are children 1–3; this proportion is similar in the US, where there are 95 000 hospital ...

Objectives Develop a score summarising how successfully a child with any surgical condition has been treated, and test the clinical validity of the score. Design Discrete choice experiment (DCE), and ...

Background The prevalence of cardiovascular anomalies in Down's syndrome is well described, but there are few data on spectrum, management and outcome. The authors aimed to provide this information ...

Kawasaki disease (KD) is an acute self-limiting inflammatory disorder, associated with vasculitis, affecting predominantly medium-sized arteries, particularly the coronary arteries. In developed ...

Benign intracranial hypertension (BIH) is a headache syndrome characterised by (1) raised cerebrospinal fluid (CSF) pressure in the absence of an intracranial mass lesion or ventricular dilatation; (2 ...