OBJECTIVE To describe a clock drawing task (CLOX) designed to elicit executive impairment and discriminate it from non-executive constructional failure. SUBJECTS 90 elderly subjects were studied (45 ...

Functional movement disorders (FMD) are proposed to reflect a specific problem with voluntary control of movement, despite normal intent to move and an intact neural capacity for movement. In many ...

Objective To determine the diagnostic and prognostic performance of serum neurofilament light chain (NFL) in amyotrophic lateral sclerosis (ALS). Methods This single-centre, prospective, longitudinal ...

Objective To determine clinical manifestations, immunotherapy responsiveness and outcomes of glutamic acid decarboxylase-65 (GAD65) neurological autoimmunity. Methods We identified 323 Mayo Clinic ...

Objective To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods Analyses used two prospective cohort studies of SVD: St. George’s ...

Background Evidence on preventing Alzheimer’s disease (AD) is challenging to interpret due to varying study designs with heterogeneous endpoints and credibility. We completed a systematic review and ...

Background In the Phase 3 OPTIMUM study ([NCT02425644][1]), patients with relapsing multiple sclerosis (RMS) treated with ponesimod (20 mg) had greater reduction in the annualized relapse rate ...

Results Records for 1,749 patients (53.9% male, mean age 37) were included in the analysis. The number of patients receiving an MRI for a specific indication were: 204 (11.7%) for an atypical ...

Functional neurological disorder (FND) is a common and disabling disorder that is often considered difficult to treat, particularly in adults. Psychological therapies are often recommended for FND.

Objective To compare outcomes after treatment with autologous haematopoietic stem cell transplantation (AHSCT) and alemtuzumab (ALZ) in patients with relapsing–remitting multiple sclerosis. Methods ...

Type 2 diabetes mellitus (DM2) is associated with moderate cognitive impairment in verbal memory, mental flexibility, and information processing speed, while other cognitive functions remain ...

Frontal lobe brain sagging syndrome is recently described syndrome, though its natural history and pro- gression remains unknown. We present a 68-year-old female with progressive worsening of ...