The carbon isotopic composition of atmospheric CH 4 (δ13 C CH4) is a powerful tool for tracking the sources and sinks of atmospheric CH 4. Different CH 4 sources have distinctive δ 13 C CH4 values: ...

A cure for chronic hepatitis B requires eliminating or permanently silencing covalently closed circular DNA (cccDNA). A pivotal target of this approach is the hepatitis B virus (HBV) X protein (HBx), ...

To better understand the potential health threats and underlying visual pathways of long-term light at night (LAN) exposure, we adopted a widely accepted diurnal animal model tree shrew (Tupaia ...

Developing oral biologics has long been a holy grail of protein engineering. Traditional antibodies are large and unstable in the presence of gastrointestinal proteases. Here, we present a strategy to ...

Greening immediately after etiolated-seedling’s emergence from the soil is critical for plants to initiate their autotrophic life cycle through photosynthesis. The greening process relies on a complex ...

Water molecules at the solid–liquid interface display intricate behaviors sensitive to small changes. The presence of different interfacial components, such as cations or functional groups, shapes the ...

Heterotrimeric G proteins act as molecular switches that control cellular responses to external signals. Small molecules that selectively inhibit these proteins are essential for studying their ...

Mycobacterium tuberculosis (Mtb) kills over a million people per year, making it a leading cause of death from infectious diseases globally. Mtb glycans are potent drivers of disease. We took ...

Cognitive function emerges from cortical network dynamics and is often impaired in neuropsychiatric disorders like epilepsy. Physics and information theory suggest that brain networks operate ...

Vibrio cholerae, known for its pathogenicity in humans, is most commonly a marine microbe that forms biofilms on chitin particles, which it can consume as a source of carbon and nitrogen. Upon ...

This work was supported by the National Natural Science Foundation of China (82272567, 82472525), the Priority Academic Program Development of Jiangsu Higher Education Institutions, Jiangsu Medical ...

Diapause is a critical survival strategy that enables insects to endure unfavorable seasonal conditions, yet the molecular mechanisms linking photoperiod cues to hormonal regulation during diapause ...